Abstract
The discovery, synthesis and structure-activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described. These compounds are structurally simple and display appropriate physical properties for CNS agents
MeSH terms
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Chemical Phenomena
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Chemistry, Physical
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Drug Design
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Humans
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In Vitro Techniques
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Indicators and Reagents
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Microsomes / drug effects
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology*
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Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Indicators and Reagents
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Pyrimidines
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Receptors, Corticotropin-Releasing Hormone
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CRF receptor type 1